Cancer waiting times Cancer information Cancer Research
In England Scotland and Northern Ireland the current targets are no more than 2 months 62 days wait between the date the hospital receives an urgent referral for suspected cancer and the start of treatment no more than 31 days wait between the meeting at which you and your doctor agree the treatment plan and the start of treatment
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G quadruplexes a promising target for cancer therapy
Cancer is the world s second most leading cause of death Although therapeutic strategies for many cancers have greatly advanced during the last years still about 9 6 million people died of cancer in 2018 This highlights the need to strengthen the research on causes of cancer development and to improve diagnostic and anti tumor treatment options
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Notch signaling An emerging therapeutic target for cancer
Mutations and amplifications of the Notch signaling often increased the expression of canonical Notch target genes resulting in the progression of cancer Notch1 rearrangements related to high N1 ICD levels in triple negative breast cancer xenografts correlated with responsiveness to GSI based therapies
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Molecular TargetsNational Cancer Institute
Molecular Targets Thousands of molecular targets have been measured in the NCI panel of 60 human tumor cell lines Measurements include protein levels RNA measurements mutation status and enzyme activity levels You can choose to search for a target
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Identifying a test to target cancer drug University of Leeds
The cancer drug panitumumab is one option for patients with advanced bowel cancer and doctors already use a genetic test called RAS to select patients who may be helped by it Even with the RAS test the drug can control symptoms and extend life for some patients but for others it is ineffective and may cause unpleasant side effects
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Heat activated grenade to target cancer ScienceDaily
Heat activated grenade to target cancer Date October 30 2015 Source Cancer Research UK Summary Researchers have developed cancer drug packed grenades armed with heat sensitive
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TARGET broadinstitute/cancer/CGA
What is TARGET TARGET tumor alterations relevant for genomics driven therapy is a database of genes that when somatically altered in cancer are directly linked to a clinical action TARGET genes may be predictive of response or resistance to a therapy prognostic and/or diagnostic TARGET is intended to be a community resource for translational oncology
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TargetCancer FoundationHome Facebook
TargetCancer Foundation Cambridge MA 1 845 likes 7 talking about this 11 were here TargetCancer promotes the development of lifesaving treatment protocols for rare cancers TargetCancer
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TARGET broadinstitute/cancer/CGA
TARGET t umor a lterations relevant for ge nomics driven t herapy is a database of genes that when somatically altered in cancer are directly linked to a clinical action TARGET genes may be predictive of response or resistance to a therapy prognostic and/or diagnostic
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Targeted Therapy for CancerNational Cancer Institute
Targeted therapy is the foundation of precision medicine It is a type of cancer treatment that targets proteins that control how cancer cells grow divide and spread As researchers learn more about the DNA changes and proteins that drive cancer they are better able to design promising treatments that target these proteins
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TargetCancer Foundation Funding Innovative Cancer
TargetCancer Foundation announces TCF 001 TRACK an innovative rare cancer precision medicine study The TargetCancer Foundation Virtual Gala raises 275 000 TargetCancer Foundation provides 240 000 in new cholangiocarcinoma research funding
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Heat activated grenade to target cancer ScienceDaily
Heat activated grenade to target cancer Date October 30 2015 Source Cancer Research UK Summary Researchers have developed cancer drug packed grenades armed with heat sensitive
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CREB1 A Potential Target for Treating Pancreatic Cancer
Preclinical experiments using cell lines genetic mouse models and human pancreatic tumor tissue identified the transcription factor CREB1 for cyclic AMP responsive element binding protein 1 as a potential therapeutic target for the treatment of pancreatic cancer according to results presented during Week 1 of the virtual AACR Annual Meeting 2021 held April 10 15
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How Targeted Therapies Are Used to Treat Cancer
Targeted therapy is a type of cancer treatment that uses drugs designed to target cancer cells without affecting normal cells Cancer cells typically have changes in their genes that make them different from normal cells Genes are part of a cell s DNA that tell the cell to do certain things
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Mechanoresponsive stem cells to target cancer metastases
Abstract Despite decades of effort little progress has been made to improve the treatment of cancer metastases To leverage the central role of the mechanoenvironment in cancer metastasis we present a mechanoresponsive cell system MRCS to selectively identify and treat cancer metastases by targeting the specific biophysical cues in the tumor niche in vivo
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Targeted Cancer Therapies Fact SheetNational Cancer
Targeted cancer therapies are drugs or other substances that block the growth and spread of cancer by interfering with specific molecules molecular targets that are involved in the growth progression and spread of cancer Targeted cancer therapies are sometimes called molecularly targeted drugs molecularly targeted therapies precision medicines or similar names
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Target Ovarian Cancer We re the UK s leading ovarian
Target Ovarian Cancer is a company limited by guarantee registered in England and Wales No Registered office 30 Angel Gate London EC1V 2PT Registered charity numbers England and Wales and SC042920 Scotland
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Metastasis a therapeutic target for cancer Nature
Metastasis remains the major driver of mortality in patients with cancer The similarities and differences between primary tumors and metastases are described and pathways controlling the
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Evolution of Cancer Treatments Targeted Therapy
Evolution of Cancer Treatments Targeted Therapy Until the late 1990s nearly all drugs used in cancer treatment with the exception of hormone treatments worked by killing cells that were in the process of replicating their DNA and dividing to form 2 new cells These chemotherapy drugs also killed some normal cells but had a greater effect on
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AKT as a Therapeutic Target for Cancer Cancer Research
Many cellular processes in cancer are attributed to kinase signaling networks V akt murine thymoma viral oncogene homolog AKT plays a major role in the PI3K/AKT signaling pathways AKT is activated by PI3K or phosphoinositide dependent kinases PDK as well as growth factors inflammation and DNA damage Signal transduction occurs through downstream effectors such as mTOR glycogen
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Targeted Therapy for Cancer Types Side Effects and Costs
Targeted cancer therapies are drugs that target specific parts of cancer cells such as proteins or genes that help cancers grow and spread They also may go after other types of
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Radiation Therapy for Cancer TreatmentTargeting Cancer
About Targeting Cancer 1 in 2 cancer patients would benefit from radiation therapy at some time during their cancer experience 1 However less than 1 in 3 patients in Australia and New Zealand will actually receive radiation therapy 2 The Radiation Oncology Targeting Cancer Campaign is an initiative of the Faculty of Radiation Oncology of the Royal Australian and New Zealand College of
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Exploiting Tumor Neoantigens to Target Cancer Evolution
Immunotherapeutic manipulation of the antitumor immune response offers an attractive strategy to target genomic instability in cancer A subset of tumor specific somatic mutations can be translated into immunogenic and HLA bound epitopes called neoantigens which can induce the activation of helper and cytotoxic T lymphocytes However cancer immunoediting and immunosuppressive mechanisms
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Tumor Evolution as a Therapeutic Target Cancer Discovery
Recent technological advances in the field of molecular diagnostics including blood based tumor genotyping allow the measurement of clonal evolution in patients with cancer thus adding a new dimension to precision medicine time The translation of this new knowledge into clinical benefit implies rethinking therapeutic strategies In essence it means considering as a target not only
Get PriceWhen the Target Isn t Really the Target One Way Cancer
The FDA approved another hugely successful targeted cancer drug Gleevec in just a few months in 2001 Today melodramatic ads pitch the new arsenal of cancer treatments Zelboraf Tafinlar Keytruda Opdivo But targeted drugs can fail if a new mutation alters the target or cancer cells find an alternate pathway that hikes cell division rate
Get PriceBGU researchers find promising target for cancer treatment
BGU researchers find promising target for cancer treatment The researchers have only studied the mechanism in breast cancer models so far but are currently expanding it to other cancer
Get PriceA Target on CancerMilwaukee Mag
A Target on Cancer How a precision treatment makes life easier on patients BY Jeff Karzen Illustration by Daniel Fishel Mark Rodziczak took the kind of blow last year that knocks men off their feet a diagnosis of prostate cancer So these days the 61 year old Delafield resident knows far more than he d like about cancer treatments
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Target CancerAn Oasis of Healing
Target and Eliminate Cancer without Causing Harm One of the most tragic truths of our world today is that most people with cancer die from the treatments not from the natural progression of cancer Dr Hardin B Jones a former professor of medical physics and physiology at the University of California Berkeley has studied the life
Get PriceAKT as a Therapeutic Target for Cancer Cancer Research
AKT as a Target in Cancer Therapy AKT is overactivated in cancer The overactivation of AKT is a common molecular characteristic of human malignancies Expression of certain oncogenes or loss of particular tumor suppressor genes can result in activation of the PI3K/AKT signaling pathway
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Tumor microenvironment as a therapeutic target in cancer
1 Introduction Cancer is a genetic disease driven by the accumulation of mutations in cancer cells Even though non cancerous cells in tumors such as stromal cells and immune cells have been known for quite some time to play critical roles in tumor progression and therapeutic responses attention has been predominantly focused on cancer cells
Get PriceGene Editing Reveals Potential Cancer Treatment Target
1 Proteomic profiling of FBXW7 mutant serous endometrial cancer cells reveals upregulation of PADI2 a potential therapeutic target Urick ME Bell DW Cancer Med 2020 Apr 5 doi 10 1002/cam4 3013 2 Exome sequencing of serous endometrial tumors identifies recurrent somatic mutations in chromatin remodeling and ubiquitin ligase complex genes
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TARGET Therapeutically Applicable Research to Generate
The Therapeutically Applicable Research to Generate Effective Treatments TARGET program applies a comprehensive genomic approach to determine molecular changes that drive childhood cancers The goal of the program is to use data to
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Targeting Notch to Target Cancer Stem Cells Clinical
For a general discussion of Notch targeting in cancer the reader is referred to 35 Here the discussion will focus on Notch as a target in CSC The strongest evidence to date for a role of Notch in CSC is in breast cancer 6 8 8284 embryonal brain tumors 85 and gliomas 86 87
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Notch signaling An emerging therapeutic target for cancer
Introduction The Notch signaling cascade is critical for cell proliferation differentiation development and homeostasis regulated Notch signaling is found in various diseases such as T cell leukemia breast cancer prostate cancer colorectal cancer and lung cancer as well as central nervous system CNS malignancies Recent evidence has demonstrated that Notch signaling is associated
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MUC16 as a novel target for cancer therapyPubMed
MUC16 as a novel target for cancer therapy Expert Opin Ther Targets 2018 Aug22 8 doi 10 1080 2018 Epub 2018 Jul 26 Authors Abhijit Aithal 1
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CREB1 A Potential Target for Treating Pancreatic Cancer
Preclinical experiments using cell lines genetic mouse models and human pancreatic tumor tissue identified the transcription factor CREB1 for cyclic AMP responsive element binding protein 1 as a potential therapeutic target for the treatment of pancreatic cancer according to results presented during Week 1 of the virtual AACR Annual Meeting 2021 held April 10 15
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